George Clooney, Julia Roberts and Matt Damon are among the stars who appear in a new advert to show their support for the Make Poverty History.
Desperate Housewives star Alfre Woodard, Don Cheadle, George's journalist father Nick Clooney, and country singer Toby Keith are among the others who appear in the ad.
The advert, which is narrated by Matt Damon, urges viewers to join the ONE campaign and help fight against extreme poverty and Aids worldwide.
Matt Damon says: "The fact that a kid is dying every 15 seconds because they don't have access to clean water and sanitation is disgusting and it's unnecessary."
"There are solutions that can be implemented if we just do it. It's pennies, it's like that old saying 'An ounce of prevention is worth a pound of cure'," he added.
The advert also calls for US congress to increase humanitarian aid by 1% of the federal budget.
